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2Loading phase: 24 weeks daily

Introduction Endoplasmic reticulum (ER) stress, which is well known as the accumulation of unfolded proteins in ER lumen caused by the increase of protein synthesis or multiple conditions, and ER responds to ER stress by activating the unfolded protein response (UPR), an adaptive intracellular signal to cope with ER stress and help to sustain cell survival and normal functions (1)

[17, 58, 91] Dietary supplementation combined with dietary reform can halt the deterioration and bring about improvement, as achieved by 94 percent of the patients with newly diagnosed RR-MS over a period of two years

Both are effective

[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Shackelford C., Long G., Wolf J., Okerberg C., Herbert R