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The search terms used included GLP-1 agonists, Glucagon-Like Peptide-1 Receptor Agonists, semaglutide, Ozempic, Wegovy, liraglutide, bone health, orthopedic surgery, arthroplasty, post-operative complications, complications, bone health, bone strength, osteogenesis, and bone metabolism. To ensure the relevance and quality of the studies, we established specific inclusion and exclusion criteria

The Semaglutide Treatment Effect in People with obesity (STEP) clinical trial programme is evaluating onceweekly subcutaneous semaglutide 2.4 mg (a glucagonlike peptide1 analogue) in people with overweight or obesity

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Preliminary lab work hints at improvements in inflammation and liver enzymes at sub-therapeutic dosesfindings Healthline notes remain early and anecdotal

A: Semaglutide is synthesized using a combination of peptide chain assembly and the addition of a fatty acid chain