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A 4-week randomized parallel placebo-controlled trial of 0, 25 or 150 mol oral sulfurophane failed to show any changes in alveolar macrophage and bronchial epithelial cell expression of genes encoding antioxidants, or in markers of inflammation in a trial of 89 patients with COPD

The gene encoding -butyrobetaine dioxygenase (also called -butyrobetaine 2-oxoglutarate dioxygenase or -butyrobetaine hydroxylase) is identified as BBOX1

Mechanistically, myristoylation promotes the recruitment of FSP1 to the plasma membrane, where it functions as an oxidoreductase, mediates the reduction of NADH-dependent CoQ, and produces a lipophilic free radical-trapping antioxidant (RTA) that inhibits the lipid peroxidation chain reaction [6, 11, 88]

Klyosov, A