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Macrophages exist in two primary "modes" or "polarizations": M1 Macrophages (The Demolition Crew): During the immediate aftermath of an injury, macrophages adopt the M1 state

None of them evaluated the long-term toxicity, nor did they conduct gene knockdown or overexpression experiments to verify the regulatory mechanisms of natural products (Wang et al., 2023c

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The alteration of amino acid metabolism in the host brain was presented based on the differentiated amino acid concentrations of plasma and brain between conventionally raised mice and germ-free mice, which attributed to the participation of gut microbiota [76]