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A prospective study involving IBD patients with aberrant metabolic profiles recorded an increase in HPRT activity following the thiopurine-allopurinol therapy but no effect on TPMT activity, suggesting that allopurinol may affect HPRT through an unknown mechanism (Seinen et al., 2013)

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The American Diabetes Association echoes this guidance, specifically advising patients to check expiration dates on insulin and GLP-1 medications like semaglutide before each use