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doi: 10.3389/fendo.2022.1092837 Received 08 November 2022 Accepted 12 December 2022 Published 04 January 2023 Volume 13 - 2022 Edited by Luna Samanta, Ravenshaw University, India Reviewed by Jelena Djordjevic, Faculty of Biology, University of Belgrade, Serbia

Possibly, this toxicity, in addition to lower esophageal sphincter and pyloric sphincter failure, involves sole NSAIDs-gastric ulcers, presenting with aspirin (and thereby, aspirin was used intragastrically) (14) and ibuprofen (10), as well as with those agents combining gastric and small intestine ulcers (i.e., diclofenac (9, 11))