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Emerging evidence indicates their potential role in the management of diverse obesity-related comorbidities, including metabolic dysfunction-associated steatotic liver disease, obstructive sleep apnea, polycystic ovary syndrome, neurodegenerative disorders, and even substance use disorders

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The direct regulation of GLP-1 on insulin expression is significant for type 2 diabetes (T2D) patients with simple glucose tolerance but normal insulin secretion ( 2 Peptide-based GLP-1 derivatives and small molecule compounds of GLP-1RA There are two main categories of GLP-1 receptor agonists, small molecule compounds and peptide-based GLP-1 derivatives as shown in Figure 1 , including exenatide, liraglutide, dulaglutide, etc