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Metformin had a lower incidence of any acidosis and severe infection in the range of the estimated glomerular filtration rates (eGFRs) of the 45 to 1000 mg/day and those treated for an extended duration greater than 3 years (Figure 2)

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Indeed, a double blinded trial (13) assessed the effects of myo-inositol on the ovarian function by comparing PCOS patients on 2g MYO + 200mcg folic acid (twice a day) for 3 months (treated group) versus PCOS patients on 200mcg folic acid (twice a day) for the same period length (control group)