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Carnitine Synthesis and Dietary Uptake In animal tissues, L-carnitine concentrations are relatively high, typically between 0.2 and 6 mmol/kg with almost all in the heart and skeletal muscle, and it is synthesised de novo in animal cells by a multi-step process with N -trimethyl-lysine derived from protein degradation as the primary precursor and butyrobetaine as an intermediate

Van Horn L, Carson JA, Appel LJ, Burke LE, Economos C, Karmally W, Lancaster K, Lichtenstein AH, Johnson RK, Thomas RJ, et al

PHA: PHA (polyhydroxy acid) is similar to alpha hydroxy acids (AHAs) such as glycolic acid and lactic acid, but is considered to be gentler on the skin

However, the mechanisms involved, whether therapeutic or side effects, are not fully understood