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JCO 12 , 194205 (1994)

Therefore, GR, by lacking crucial regions of the ligand-binding domain, was previously assumed to be unable to bind glucocorticoids, translocate into the nucleus, or directly regulate gene expression

5 Protective effects of PCs on diabetes mellitus and complications 5.1 PCs and type 1 diabetes mellitus Type 1 diabetes originates as an autoimmune disease involving the targeted destruction of pancreatic islet -cells due to specific immune reactions