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The therapeutic efficacy of GLP-1RAs is underscored by their ability to significantly lower glycated hemoglobin (HbA1c) levels, with reductions ranging from 0.42% to 1.6% depending on the formulation and duration of treatment

That creates uncertainty for patients who may begin treatments that many experts view as lifelong therapies

Adding pyridoxine to compounded semaglutide may help patients tolerate the titration phase more comfortably, particularly during the first 8 weeks when nausea is most likely

Acknowledgements We appreciate the help of the CBMSO Facilities, in particular Microscopy and Animal Care and the technical assistance of Laura Lpez

Excellus Blue Cross Blue Shield does as well