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doi: 10.1210/endo.132.2.8425500 71 PetrykAFleenorDDriscollPFreemarkM

Gozes group has found that ADNP mutations affect MT dynamics and inhibit its interactions with Tau [348, 349], producing a tauopathy-like phenotype manifested in increased GSK-3 activity, Tau hyper-phosphorylation, and cognitive deficiency [293]

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How well it works In the ATTAIN-1 trial, people on the top 17.2 mg dose who stayed on treatment lost about 12.4% of their body weight at 72 weeks , against roughly 0.9% on placebo (Lilly, ATTAIN-1)

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