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If anxiety, depression, hallucination, seizures, cranial nerve weakness, and paresis of the extremities are associated with vomiting and abdominal pain, detection of increased urinary -aminolevulinic acid and porphobilinogen in spot urine during the episode confirm the diagnosis of acute intermittent porphyria

The degradation of heme and release of iron by the reaction with GSH was first described by Atamna and Ginsburg to occur in membranous bound heme at physiological pH [25]

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ingluviei in all the treatment groups compared to T1 and in M