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481,482 (4) A fourth targeted drug approach is the activation of PPAR- in mature adipocytes that then induces altered expression of several genes (increased GLUT4 and adiponectin expression, along with decreased TNF-, IL-6 and leptin expression) involved in the insulin signaling cascade, thereby improving insulin sensitivity

The compound functions by activating ghrelin receptors in the areas of the brain that regulate growth hormone (GH) release

Both receptors display a differential expression in normal tissues

Finally, integration into existing wound-care protocols through collaborations with clinicians and industry partners can facilitate adoption

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