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Journal Pharmacology 967, 176356

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In PCOS granulosa cells, elevated phosphorylation of the pro-apoptotic protein BAX, coupled with suppressed phosphorylation of the anti-apoptotic protein BCL-2, enhances mitochondrial pathway apoptosis, accelerating follicular atresia ( 3.6 Chronic low-grade inflammation Chronic low-grade inflammation have been identified as a central component in the pathogenesis of PCOS, rather than mere accompanying phenomena

Patients with gastrointestinal diseases, like gastric ulcers, leaky gut, irritable bowel syndrome, and Crohns disease

Holt DA, Levy MA, Metcalf BW