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KEAP1 cysteine oxidation then stabilizes NRF2 to allow its nuclear translocation, but chronic infection dysregulates this pathway, permitting ROS accumulation

Glutathione is an antioxidant naturally produced by the liver that supports key bodily functions, including tissue repair, protein and chemical production, and immune system activity

Strikingly, Gclc ablation increased mTORC1 activation in FoB to a level similar to that found in MZB

Glutathione binds to tyrosinase, slowing pigment formation