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What are the concerns about compounded GLP-1 drugs

GIPR agonism could exert beneficial metabolic effects by enhancing glucose-stimulated insulin secretion, increasing postprandial adipose tissue blood flow and triglyceride storage, and by attenuating weight loss-induced bone loss by decreasing bone resorption and increasing osteoblast activity

Beyond the gut, people who took GLP-1 medications were also more likely to be diagnosed with problems in their bones and joints, like arthritis and tendinitis, compared with people taking other medications to manage their blood sugar

Dulloo AG

Weight loss from these medications can occur so rapidly that the skin doesnt have time to catch up, leading to sagging and a loss of firmness