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Pharmacokinetic studies need to standardise serum and CSF determination of NAC levels and correlate them with clinical and mechanistic outcomes

One vehicle-controlled study of combination brimonidine 0.33% gel with ivermectin 1% cream over a period of 12 weeks found that the combination treatment was significantly statistically superior to placebo and statistically significant to regimens that used brimonidine for a shorter period of time in conjunction with ivermectin.10 In addition to use with other topical pharmacological agents, oxymetazoline has been studied in combination with device therapy for rosacea

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Torres J, Mehandru S, Colombel JF, Peyrin-Biroulet L

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