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Studies have demonstrated that EGCG can directly influence mitochondrial bioenergetics by enhancing the efficiency of the electron transport chain and promoting mitochondrial biogenesis through activation of key signaling pathways, particularly peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1)

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It plays a critical role in cellular energy production and protects cells from oxidative damage

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Deoxycholic acid, for example, signals through TGR5, leading to PKA inhibition and has been linked to EGFR activation, ERK1/2 signaling, and occludin redistribution in Caco-2 cells (57, 58)