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Patient Input CADTH received 1 patient group submission from the International Coalition of Organizations Supporting Endocrine Patients (ICOSEP)

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We found that when IRE1 was depleted in MDA-MB-231 triple-negative breast cancer cells, these cells became significantly more resistant to ferroptotic cell death induced by either erastin, an inhibitor of the cystine-glutamate antiporter SLC7A11, or cystine depletion (Fig

, 16 , 1303-1314, doi: Nishizawa, S., Araki, H., Ishikawa, Y., Kitazawa, S., Hata, A., Soga, T., and Hara, T