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LL-37 released from neutrophil extracellular traps (NETs) binds crystals, forming pro-inflammatory complexes that trigger an IL-1 storm
J Pharm Pharm Sci 26:11808 Neamatallah T, El-Shitany NA, Abbas AT, Ali SS, Eid BG (2018) Honey protects against cisplatin-induced hepatic and renal toxicity through inhibition of NF-B-mediated COX-2 expression and the oxidative stress dependent BAX/Bcl-2/caspase-3 apoptotic pathway
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The Mary&May Tranexamic Acid and Glutathione Eye Cream addresses both: Tranexamic Acid disrupts the signalling pathway that drives surface pigmentation, while Glutathione shifts melanin synthesis toward lighter production through cellular antioxidant activity that also addresses the oxidative conditions contributing to vascular visibility
Autoimmune responses can damage these powerhouses, leading to cellular fatigue and further inflammation
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