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doi: 10.1210/EN.2013-1934 4 DruckerDJHabenerJFHolstJJ

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What This Means for Peptide Therapy Patients Peptide compounds like Sermorelin or CJC-1295/Ipamorelin are increasingly used for: Anti-aging protocols Post-injury recovery Energy, sleep, and muscle support But without understanding IGFBP-3, these therapies may: Look falsely effective (if IGF-1 rises but free IGF-1 is excessive) Pose hidden risks (if protective binding is insufficient) We use IGF-1 : IGFBP-3 ratio analysis as a tool for: Refining dosage Adjusting protocols Monitoring cancer risk Supporting safe, individualized regenerative therapies Functional Testing in a Root-Cause Framework At Internal Healing & Wellness MD, we use advanced lab testing to interpret growth hormone signaling, assess whole-body function, and guide individualized protocols