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NAC potentially activates the Nrf2 pathway through a distinct, GSH-independent mechanism involving hydrogen sulfide (H 2 S) (Figure 2)

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Suffers of the serious genetic condition phenylketonuria (PKU) are unable to convert phenylalanine to tyrosine, whilst patients with alkaptonuria have a defective tyrosine metabolism, producing distinctive urine which darkens when exposed to the air