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[127] Emerging data from the STEP UP trial, reported in January 2025, tested higher-dose semaglutide at 7.2 mg weekly in obese adults without diabetes, achieving a mean 20.7% weight reduction over 68 weeks, superior to 2.4 mg (15.3%) and placebo (2.6%), with comparable tolerability

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Conclusion: Indias Semaglutide LoE: A strategic blueprint for global obesity care Indias Semaglutide LoE is not just a market event, its a strategic inflection point with global implications

The Sonic hedgehog (Shh) signaling pathway has a key role in stem cell behavior, organ differentiation, embryonic development, axonal growth and regulation in the developing as well as the adult brain [14,15,16]