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The index encounter was defined as the first instance of a GIP/GLP-1 RA prescription or a randomly selected encounter for patients without such prescriptions, both occurring after a first diagnosis date of OUD or AUD

As such, it becomes difficult to properly evaluate the impact that differences in redox sensitivity may have on determining response to APR-246

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This action is working in conjunction with the brain as it influences appetite suppression and energy expenditure by interacting with neuronal circuits that regulate hunger and fullness (Zhang et al