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Streptozotocininduced diabetic models in mice and rats

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Berberine (Berberis aristata bark powder) Berberine is a bioactive compound extracted from several plants , including Berberis aristata

Notably, the activation of UPR is intimately related to three transmembrane ER-resident stress sensors: inositol-requiring enzyme 1 (IRE1), PKR-like ER kinase (PERK) and activating transcription factor (ATF6), which acts as regulators of cell fate under ER stress by integrating information about the intensity and duration of the injury

Figure 39: Photograph of Professor Matthias Tschp, 2017 credit: Astrid Eckert / TU Muenchen, Wikipedia