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In pregnant rabbits given 0.2, 2, 22, 156, or 260 mcg/kg/day exenatide during fetal organogenesis, irregular fetal skeletal ossifications were observed at 2 mcg/kg/day, a dose yielding systemic exposure up to 12-times the human exposure from the MRHD of BYETTA based on AUC comparison

Ben: Or Rybelsus, which just got FDA approval pretty recently

These medications require a prescription from a licensed clinician and aren't suitable for everyone

Inside the cell, it is deoxygenated and reduced to Fe 2+ by iron oxide reductase

AB contributed with data acquisition, critical manuscript revision and final manuscript approval