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In addition, the magnitude of the shear force affects the activation status of neutrophils, and an excessively large shear force can lead to a loss of neutrophil activity and function ( 4.6 NETs NETs are extracellular networks of DNA, histones, microbicidal proteins, and oxidative enzymes that are released by activated neutrophils in response to various stimuli, including viral and inflammatory cytokines (86, 87)

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AEs also vary in their reversibility

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