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Treatment options discussed in the literature include noninvasive (high-intensity focused ultrasound, HIFU, radiofrequency), minimally invasive (fillers, biostimulators) and surgical procedures (facelifting, fat grafting)

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Clinical trials are ongoing with small-molecule TNF--converting enzyme, p38 mitogen-activated protein kinase and phosphodiesterase inhibitors that specifically interrupt the synthesis and signalling pathways for TNF- and downstream pro-inflammatory molecules such as IL-1, IL-6, nitric oxide synthase and cyclooxygenase-2