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When stratified by administration route, the average percentage reductions were: Intramuscular (IM): 48.3% Sublingual: 30.7% Oral: 30.3% These results suggest that IM administration leads the most pronounced homocysteine reduction, however, sublingual and oral routes also demonstrate clinically relevant effects

Australian Government Department of Health

People who feel persistently tired or mentally foggy while many factors can contribute to these feelings, insufficient B12 availability is a common and often overlooked one

Studies have suggested that low B 12 levels may trigger MS, make MS symptoms worse, or be caused by MS

Treatment doses depend on the cause: pernicious anaemia typically requires intramuscular hydroxocobalamin 1,000 micrograms three times weekly initially, whilst dietary deficiency may be treated with oral cyanocobalamin 50150 micrograms or 1,000 micrograms daily