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The strongest evidence remains in topical applications, while injectable GHK-Cu should be viewed as an investigational compound with unknown safety profiles

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Egerton A, Brugger S, Raffin M, Barker GJ, Lythgoe DJ, McGuire PK, et al

Furthermore, in macrophages triggered by the TLR agonists LPS or TNF-, D10G irreversibly blocks cytoplasmic IKK-catalysed IB phosphorylation and IKK vector elicited NF-B transcriptional activity to minimize inflammatory signals (235)