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203,204 Delivery of substrates to the 26S proteasome for degradation To avoid the deleterious accumulation of unfolded intermediates, the protein extracted from the ER needs to enter the 26S proteasome to enable effective degradation

Both have been shipping to Canadian pharmacies since May 20, 2026 at roughly $88 to $99 per month at Costco Pharmacy and $100 to $120 at most chain pharmacies, a 50 to 70 percent drop from branded pricing for the diabetes indication

Neuropharmacology (2018) 136(Pt B):2519

Medicare Extra Help (Low Income Subsidy) Social Security Administration ssa.gov/medicare/part-d-extra-help Eligibility requirements, income and asset limits, and how to apply for Extra Help to reduce Part D drug costs in Washington State

Plaintiffs argue this is insufficient