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Reduced sensitivity to endogenous GLP-1R signaling is reported in metabolic disease 69,70 , where impairment of the intestinotrophic actions of GLP-1R and GLP-2R could extend to obesity

Occasionally, it may develop elsewhere in the body

Chronic or recurring pancreatitis develops more gradually, causing persistent mild-to-moderate pain, weight loss despite treatment, and digestive difficulties like oily stools

they are not a substitute for balanced nutrition and movement

Novo Nordisk and its competitor Eli Lilly are expected to make more than $100 billion in revenue from their GLP-1 drugs, including new oral weight-loss medications