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On the other hand, SGLT-2is causes early benefit on heart failure than GLP-1RAs, shows improved hemodynamics and sympathetic inhibition, and is frequently applied for treatment of T2D patients with higher risks of progression to severe heart failure

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It is a small protein called a tri-peptide meaning it

Modulates glutathione levels by enhancing synthesis and preventing depletion, bolstering endogenous antioxidant defenses

Conversely, blocking DKK-1 or SOST restores Wnt activity, elevates OPG levels, and reduces osteoclast differentiation (56)