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While proliferation of HCT116 cells was not affected by knocking down PGRMC1, PGRMC1-KD cells were more sensitive to the EGFR inhibitor erlotinib than control HCT116 cells, and the knockdown effect was reversed by co-expression of shRNA-resistant wild-type PGRMC1 but not of the Y113F mutant (Fig

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The activities of manganese superoxide dismutase and glutathione-S-transferase, which detoxify superoxide and other electrophilic substances, respectively, are also inhibited by nitration (203, 346)

Manufacturing involves dissolving stabilizers and preservatives into water-based solutions, making them easy to spray on

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