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Although the predominance of available literature from in vivo ischemic studies has focused on the involvement of synaptic vesicle zinc, it is likely that intracellular zinc accumulation during ischemia is achieved through a possible synergism of zinc release from both synaptic and intracellular stores of zinc, as most recently demonstrated during global ischemia (38) and reported in other experimental paradigms (4551)

After 1 or 6 h, the mice received 1.5 g/kg of glucose solution (Gibco) by IP injection

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Sperm assessment was done before and after the treatment

10.1056/NEJMra072067 N