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Vamifeport (VIT-2763), as a novel oral FPN inhibitor, induces dose-dependent internalization and ubiquitination of FPN in cells, improving iron homeostasis in mouse models of -thalassemia

In the STEP 1 trial, of the average 13.6-kgweight reduction, 8.3 kg (62%) was fat mass and 5.3 kg (38%) was lean body mass (including muscle and other nonfat tissues) [14]