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By Jim Robbins While relief could come to the Great Lakes and parts of the Northeast over the weekend, the Mid-Atlantic and Southeast will stay hot

Do not wait for routine labs Severe daytime sedation, confusion, breathing pauses during sleep, or worsening mood symptoms need clinical review

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This results from the impairment of bloodbrain barrier tight junction expression, endothelial cells, and alterations to transport pathways caused by proinflammatory cytokines, LPS, toxic activated T cells (e.g., CD40L + ), ROS, O&NS, neurovascular dysfunctions, and increased free cholesterol levels [1, 205,206,207,208]