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Allergy 65, 590596 (2010)

doi:10.1126/science.8351519

Protein intake and Phe tolerance decrease with age, which can be explained by slower growth, and blood Phe levels increase in sick patients as there is a higher energy demand and the catabolism of muscle proteins is elevated during illness [79, 80]

Clinical pharmacokinetic studies consistently show that oral administration of GlyNAC leads to a rapid, dose-dependent increase in circulating plasma levels of both amino acids, typically reaching peak concentrations within just one to two hours of ingestion

17 In the initial literature, two thirds of the subjects reported symptoms of MCA, including urticaria, flushing, asthma, anaphylaxis, and episodic GI distress