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Matrix metalloproteinases MMP2 and MMP9 are upregulated by noradrenaline in the mouse neuroendocrine hypothalamus

Keshavarz Shahbaz S, Koushki K, Izadi O, Penson PE, Sukhorukov VN, Kesharwani P, Sahebkar A

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These resistance-associated genes also overlapped with those identified in an additional genetic screen seeking to identify drivers of estrogen-independence - with CSK also as a shared top hit suggesting that the identified genes are relevant for general endocrine resistance (and perhaps G1 arrest), rather than representing a giredestrant-specific resistance program 36