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GLP-1-GIP co-agonist tirzepatide was approved by the US Food and Drug Administration in 2022 for the treatment of T2DM (Nogueiras et al., 2023)

It also inhibited Bcl-2 expression and promoted Bax expression and caspase-3 cleavage

This is due to an enzyme called dipeptidyl peptidase-4, or the DPP-4 enzyme, which rapidly degrades natural GLP-1, making it too fleeting to provide a lasting therapeutic benefit for blood sugar control or weight management

Although preliminary evidence suggests that GLP-1 RAs may play a role in managing psoriasis and HS through both metabolic and immunologic mechanisms, current data are limited to early-phase studies and case reports

By keeping your skin hydrated and avoiding harsh ingredients, you can alleviate your symptoms and maintain healthy, KP-free skin