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Immunohistochemical staining for GLP1-R, insulin, and proinsulin immunoreactivity Membranous immunoreactivity of GLP- 1R and cytoplasmic immunoreactivity of insulin and proinsulin were evaluated semi-quantitatively using the immunoreactive score (IRS) [17]

Tolerability profile consistent with the incretin class, with gastrointestinal events most commonly reported in studies (e.g., nausea, diarrhoea, and constipation)