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Compensatory overproduction of pancreatic islets and eventual development of hyperinsulinemia, result in elevated hepatic synthesis and accumulation of total cholesterol (TC) and elevated low-density lipoprotein (LDL) levels, leading to inactivation of the enzyme LDL lipase, which is critical for cholesterol clearance

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cAMP was then assayed by HTRF (Cisbio cAMP Dynamic 2) using a Spectramax i3x plate reader (Molecular Devices)