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When you look at the overall cost of treating obesity with these medications, the numbers are staggering

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Notably, FGF21 analogs have reduced insulin resistance or decreased liver fat in clinical trials 16,26

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You can not be treated with phentermine if you: Already on another stimulant medication (like ADHD medications) History of stroke, heart attack, heart disease or uncontrolled high blood pressure (unless cleared by cardiologist) Chronic kidney disease (unless cleared by nephrologist) Nursing, Pregnant, or trying to get pregnant You can still use phentermine if you have any other medical conditions not listed above