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In one study, three healthy male subjects receiving daily subcutaneous MT-II dosed at 0.01 mg/kg variously reported the following side effects during the two-week course of administration [1]: Moderate to severe nausea Repetitive yawning and stretching Spontaneous erections Fatigue Drowsiness Additional studies have linked MT-II administration with the darkening of pre-existing naevi (moles) and the development of new ones

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1 Eli Lilly released the topline results from its TRIUMPH-1 trial on 21 May 2026