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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that works by mimicking GLP-1, a naturally occurring hormone, to manage blood sugar levels and promote weight loss through several mechanisms: Delaying gastric emptying to prolong fullness and reduce hunger
Secondary objectives included comparing the effects of semaglutide 2.4 mg to placebo with regards to mortality, cardiovascular risk factors, glucose metabolism, body weight and renal function
A subset of patients find that their body's response plateaus on tirzepatide after initial success, or they achieve their goal weight and seek a maintenance-phase medication with potentially milder side effects
Researchers are studying how GLP-1 receptor agonists affect the brain and emotions, but more data is needed
There is also a risk of dehydration due to gastrointestinal complaints and reduced food and fluid intake
