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Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1

Tumor necrosis factor induces DNA replication in hepatic cells through nuclear factor kappaB activation

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It is also a cautionary illustration of how much context a mechanism carries: the best-characterized KPV effect depends on an intestinal transporter (PepT1) abundant in gut epithelium, which is one reason KPV has been explored mainly for oral delivery in bowel inflammation rather than as a general-purpose systemic anti-inflammatory