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Moreover, the increase in glycolysis has been demonstrated to be key for IL-6, IL-8, CCL-2 and CXCL-10 expression induced by TNF- in RA-FLS 17

Further, NICE and the BNF says that if there are neurological symptoms present, then every other day injections are the recommended treatment, so all the points you make about B12 being stored and sufficient are not really relevant

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