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Addition of the ISR agonist Sephin1 to cultured human OLmaintained under control conditions or exposed to ongoing metabolic stressreduced process outgrowth 42 , suggesting that the ISR regulates the protein synthesis machinery required for OL process outgrowth and maintenance

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JAMA Neurol 79:121130 Gurney ME, Cutting FB, Zhai P et al (1996) Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis