Herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections represent significant clinical challenges, particularly in patients with DM [12, 13]
The legal challenges facing Ozempic and similar GLP-1 drugs emphasize the critical need for patients to be fully aware of the potential adverse effects of these medications, especially those with serious health consequences
However, only the injectable form has been available because peptide drugs are usually not suitable for administration via the oral route, as they present low oral bioavailability, are inactivated when they reach the gastrointestinal tract, and have low rates of diffusion into the cell [31, 32]
Regarding the safety outcomes of gastrointestinal adverse drug events (ADEs), orally administered semaglutide showed statistically similar associations with the injectable formulation ( The present study aimed to identify new signals indicating potential safety risks associated with semaglutide in the FAERS database and on social media platforms
This finding in women is consistent with prior reports suggesting that GLP-1 RAs may produce more pronounced weight loss and glycemic improvements in female people, potentially due to sex-specific differences in GLP-1 receptor expression, pharmacodynamics, or hormonal interactions [21]
